Pharmaceuticals by Air Freight to America

Why airfreight for pharmaceuticals?

Pharmaceuticals require speed, control, and traceability — three core qualities of airfreight. Medicines, vaccines, and biologics are valuable, time-sensitive, and temperature-sensitive. Sea freight takes weeks and provides insufficient control over the cold chain. Airfreight takes 1–3 days — with continuous monitoring.

Schiphol is one of Europe’s leading pharma cargo hubs: KLM Cargo's Pharma Gateway Amsterdam (PGA) is certified for GDP transport and offers specialized storage and handling facilities for pharmaceutical airfreight right at the airport.

When is airfreight essential for pharma?

• Clinical trials: samples and study medications must arrive exactly on time
• Acute drug shortages where every day counts
• Vaccines and biologics with short shelf life or strict cold chain
• High-value APIs where delay risk is unacceptable
• Compassionate use: individual patient shipments

Exporting to the United States

The US is the world’s largest importer and a top destination for Dutch exporters. Schiphol offers daily direct cargo flights to New York (JFK), Los Angeles (LAX), Chicago (ORD), and Atlanta (ATL), with a flight time of approximately 9 hours. Due to the large capacity, air freight rates to the US are generally competitive.

US Customs & Border Protection (CBP)

US customs require a correct Airway Bill, commercial invoice, and packing list for every shipment. Shipments over $800 require a formal customs entry (ISF filing). Electronics, pharmaceuticals, and dual-use goods may require additional licenses, such as an EAR export license or FDA registration of the manufacturer.

What you need to know

• Lithium batteries are subject to IATA DGR rules — always notify in advance
• Certain goods fall under EAR (Export Administration Regulations) and require a BIS license
• The US has no VAT but does impose customs duties — your buyer pays these upon import
• ISF 10+2 filing is mandatory for sea freight; for air freight, AMS (Advance Manifest System) applies

Aircargo.nl handles complete export documentation to the US and has established relationships with US customs agents at all major hubs.

Key considerations for pharmaceutical airfreight

GDP transport mandatory

Pharmaceuticals must be transported in accordance with Good Distribution Practice (GDP) guidelines. This means a continuous cold chain with temperature recording, certified storage, and documentation proving that the temperature stayed within the required range throughout transport. Aircargo.nl works only with GDP-certified handlers and airlines.

Temperature requirements

Most pharmaceutical products require transport at 2–8°C (cold chain) or 15–25°C (room temperature). Biologics, vaccines, and certain diagnostics require -20°C or colder (frozen transport). Every shipment is equipped with a calibrated temperature logger and a temperature excursion report when applicable.

Regulatory documentation

• GDP certificate from the shipper
• Import or export license depending on product type and destination country
• Controlled substances: DEA license (US) or national narcotics permit
• Batch release certificates for biologics